Mwape has been admitted at the University Teaching Hospital for weeks.
The evacuation of Mwape comes a few days after another top government official Mike Mulongoti was evacuated to South Africa for specialist treatment.
Acting President Inonge Wina authorised the evacuation of Mwape to South Africa for specialist treatment.
Mwape, who has been in admission in the University Teaching Hospital for the last nine days, will be flown to South Africa this morning (Thursday).
Speaking from his hospital bed, Lupando thanked His Excellency Edgar Lungu, President of the Republic of Zambia and Wina for the love and care showed to him.