Dr Phiri, 68, died this morning at the University Teaching Hospital Cancer Hospital where he had been undergoing treatment.
Other than his illustrious medical career, Dr Phiri was also a broadcaster of note and an educator.
Dr Phiri had prior to be admitted at the University Teaching Hospital been receiving specialized treatment at Awryp Medical Centre in Johannesburg where he was evacuated in January 2019.
He was sent back home last week after his condition deteriorated and considered terminal.
Dr Phiri went public in 2016 about his condition that he revealed had been gnawing at him from 2014.
He was co-founder of the Prostate Cancer Foundation of Zambia (PCFZ) with late broadcaster Chanda Chimba III.